# MAP3K1 Scientist Review Card

## Recommended action
open_first

## Triage score
high priority

## Reasons
- Large low-confidence fraction: 0.564 of residues are below pLDDT 70.
- Substantial very-low-confidence fraction: 0.490 of residues are below pLDDT 50.
- Longest low-confidence segment spans chain A residues 870–1178 (309 residues).
- Low C-alpha contact density suggests an extended, uncertain, or weakly packed predicted arrangement.

## Inspection checklist
- Inspect chain A residues 870–1178 first.
- Compare high-confidence regions against low-confidence or extended regions.
- Use this card to prioritize manual structural review, not to infer mechanism.
- Review source file hash and downloads before reusing the result.

## Warnings
- Structural triage only.
- No biological validation, binding prediction, stability prediction, inhibitor analysis, clinical guidance, or pharma-grade decision support.