{
  "claim_boundary": {
    "allowed": "Structural triage assistant for AlphaFold/AFDB protein structures; helps prioritize manual review.",
    "not_allowed": [
      "biological validation",
      "biological truth claim",
      "protein-stability prediction",
      "binding prediction",
      "inhibitor analysis",
      "clinical guidance",
      "pharma-grade decision support",
      "replacement for expert structural biology"
    ]
  },
  "governed_qc": {
    "model": "gpt-4.1-2025-04-14",
    "note": "This page shows the Stage 1 V3.1 governed validation gate summary. It is not a fresh live X-40 call for this browser page.",
    "policy_reason": "BIOMOL_QC_REVIEW_CONTRACT",
    "profile": "biomol_qc_review",
    "released_output_mode": "biomol_qc_review_contract_json",
    "stage1_v3_1_100_card_review": {
      "mean_clarity": 4.96,
      "mean_overclaim_risk": 0.3,
      "mean_usefulness": 3.95,
      "parse_success": "100/100"
    },
    "status": "validation_gate_summary_not_live_per_result_call"
  },
  "metrics": {
    "atom_count": 11522,
    "ca_contact_density": 0.00110888,
    "ca_contact_possible_pairs": 1136278,
    "ca_contacts": 1260,
    "contact_density_label": "low / extended or uncertain packing",
    "contact_density_method": "C-alpha contact density, distance <= 8.0 A, excluding same-chain sequence separation <= 4",
    "longest_low_confidence_segment_lt70": {
      "chain": "A",
      "end": 1178,
      "length": 309,
      "mean_confidence": 31.77,
      "mean_confidence_label": "very low",
      "min_confidence": 24.47,
      "start": 870,
      "threshold": 70.0
    },
    "longest_very_low_confidence_segment_lt50": {
      "chain": "A",
      "end": 1165,
      "length": 292,
      "mean_confidence": 30.5,
      "mean_confidence_label": "very low",
      "min_confidence": 24.47,
      "start": 874,
      "threshold": 50.0
    },
    "mean_plddt": 58.747,
    "median_plddt": 52.265,
    "plddt_lt_50_count": 741,
    "plddt_lt_50_fraction": 0.490079,
    "plddt_lt_70_count": 853,
    "plddt_lt_70_fraction": 0.564153,
    "residue_count_ca": 1512,
    "triage_score_numeric": 80
  },
  "mode": "static_batch_showcase_real_artifact",
  "ranges": [
    {
      "chain": "A",
      "end": 1178,
      "length": 309,
      "mean_confidence": 31.77,
      "mean_confidence_label": "very low",
      "min_confidence": 24.47,
      "start": 870,
      "threshold": 70.0
    },
    {
      "chain": "A",
      "end": 298,
      "length": 298,
      "mean_confidence": 34.57,
      "mean_confidence_label": "very low",
      "min_confidence": 25.08,
      "start": 1,
      "threshold": 70.0
    },
    {
      "chain": "A",
      "end": 548,
      "length": 52,
      "mean_confidence": 38.7,
      "mean_confidence_label": "very low",
      "min_confidence": 25.45,
      "start": 497,
      "threshold": 70.0
    },
    {
      "chain": "A",
      "end": 440,
      "length": 40,
      "mean_confidence": 42.12,
      "mean_confidence_label": "very low",
      "min_confidence": 27.73,
      "start": 401,
      "threshold": 70.0
    },
    {
      "chain": "A",
      "end": 627,
      "length": 29,
      "mean_confidence": 37.27,
      "mean_confidence_label": "very low",
      "min_confidence": 27.05,
      "start": 599,
      "threshold": 70.0
    }
  ],
  "run_id": "MAP3K1-demo",
  "scientist_card": {
    "inspection_checklist": [
      "Inspect chain A residues 870\u20131178 first.",
      "Compare high-confidence regions against low-confidence or extended regions.",
      "Use this card to prioritize manual structural review, not to infer mechanism.",
      "Review source file hash and downloads before reusing the result."
    ],
    "reasons": [
      "Large low-confidence fraction: 0.564 of residues are below pLDDT 70.",
      "Substantial very-low-confidence fraction: 0.490 of residues are below pLDDT 50.",
      "Longest low-confidence segment spans chain A residues 870\u20131178 (309 residues).",
      "Low C-alpha contact density suggests an extended, uncertain, or weakly packed predicted arrangement."
    ],
    "recommended_action": "open_first",
    "triage_score_label": "high priority",
    "warnings": [
      "Structural triage only.",
      "No biological validation, binding prediction, stability prediction, inhibitor analysis, clinical guidance, or pharma-grade decision support."
    ]
  },
  "source": {
    "database": "AlphaFold Protein Structure Database / AFDB-compatible source",
    "entry_url": "https://alphafold.ebi.ac.uk/entry/Q13233",
    "source_pdb_url": "https://alphafold.ebi.ac.uk/files/AF-Q13233-F1-model_v6.pdb",
    "structure_file_name": "AF-Q13233-F1-model_v6.pdb",
    "structure_file_url": "/structures/batch-demo/AF-Q13233-F1-model_v6.pdb",
    "structure_sha256": "f967885044bd3d92562245232397da336d63adbf452261b7bcfd2de3eb338c0d"
  },
  "status": "REAL_STRUCTURE_REAL_COMPUTED_METRICS_STATIC_BATCH_SHOWCASE",
  "target": {
    "afdb_model": "AF-Q13233-F1",
    "category": "kinase / structural triage",
    "name": "MAP3K1",
    "uniprot_accession": "Q13233"
  }
}